A distressing or dangerous situation.

A difficulty, problem, condition, or action contributing to such a situation.

A person liable to place others or themselves in such a situation.

The state of being troubled, disturbed, or distressed mentally; unease, disquiet.

Objectionable feature of something or someone; problem, drawback, weakness, failing, or shortcoming.

Violent or turbulent occurrence or event; unrest, disturbance.

Efforts taken or expended, typically beyond the normal required.

Difficulty in doing something.

Health problems, ailment, generally of some particular part of the body.

A malfunction.

Liability to punishment; conflict with authority.

(mining) A fault or interruption in a stratum.

(Cockney rhyming slang) Wife. Clipping of trouble and strife.

(slang, dated) An unplanned, unwanted or undesired pregnancy.

(transitive, now rare) To disturb, stir up, agitate (a medium, especially water).

(transitive) To mentally distress; to cause (someone) to be anxious or perplexed.

(transitive) In weaker sense: to bother or inconvenience.

(transitive, of ailments, etc.) To physically afflict.

(reflexive or intransitive) To take pains (to do something); to bother.

(intransitive) To worry; to be anxious.